There is a certain irony to the cross in the bottom of Vaso Veladora.
The church and changing monarchs have had a very ambiguos relationship to the spirit. In a short period in the 1600’s mezcal was outright prohibited. Not for religous reasons though, but to boost sale of imported spanish spirits. The church was brought in to help keep up the sales, by making local produced spirits sinful.
Archbishop Juan Antonio de Vizarron, Count of Fuenclara, and Count of Revillagigedo, viceroys of Mexico were amongst the many who tried to reign in the spirit, but eventually went the way of all other statesmen. They put a tax on it.
Pulque, which is the naturally fermented and undistilled predecessor to to mezcal, was originally a drink only meant for the indian priests in precolumbian time, so perhaps it IS quite fitting that these older deities have been replaced with the symbol of other deities in the bottom of the mezcal vessels.